Abstract
AbstractThe uptake and depuration rate constants for [14C]2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (14C‐TCDD) in growing rainbow trout were obtained in a laboratory experiment involving a 6‐h static water uptake exposure at 107 ng/L (ppt) followed by a 139‐d flow‐through depuration period. Improved mathematics were developed for estimating uptake and depuration rate constants and an equilibrium bioconcentration constant that accounts for growth dilution of the total chemical body burden. The uptake and depuration rate constants (k1' and k2) for 14C‐TCDD in rainbow trout (whole fish) were determined to be 108 ± 3 ml water/g whole fish/d and 0.012 ± 0.001 d−1, respectively. Based on these data, the equilibrium bioconcentration constant for TCDD, defined as the ratio of uptake to depuration rate constants, was 9,270 ± 1,050, and the elimination half‐life, t1/2, of the total body burden was 58 ± 5 d. Clinical observations of the fish concurred with those previously reported by other researchers.
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