Abstract
Cyclodextrins (CD) are a group of cyclic oligosaccharides with a cavity/specific structure that enables to form inclusion complexes (IC) with a variety of molecules through non-covalent host-guest interactions. By an elegant combination of CD with biocompatible, synthetic and natural polymers, different types of universal drug delivery systems with dynamic/reversible properties have been generated. This review presents the design of nano- and micro-carriers, hydrogels, and fibres based on the polymer/CD supramolecular systems highlighting their possible biomedical applications. Application of the most prominent hydrophobic aliphatic polyesters that exhibit biodegradability, represented by polylactide and polycaprolactone, is described first. Subsequently, particular attention is focused on materials obtained from hydrophilic polyethylene oxide. Moreover, examples are also presented for grafting of CD on polysaccharides. In summary, we show the application of host-guest interactions in multi-component functional biomaterials for controlled drug delivery.
Highlights
Supramolecular chemistry aims to construct highly complex, functional systems through a variety of noncovalent interactions [1]
The structure of CDs is described as a truncated cone with a hydrophilic outer surface and hydrophobic core that allows for the encapsulation of a variety of bioactive guest molecules
After oxidation of Fc, NPs became unstable as a glucose/glucose oxidase (GOD) environment can be achieved by gentle oxidation of Fc end-group result of cleavage of the inclusion complexes (IC) between β-CD and further BSA may be released in a controlled manner
Summary
Supramolecular chemistry aims to construct highly complex, functional systems through a variety of noncovalent interactions (e.g., multiple hydrogen bonding, metal coordination, host–guest interactions, and aromatic stacking) [1]. Grafting from and grafting to methods arethe used to the CDs the formation well-defined relatively uniform polymers with ability to combine form host-guest with saccharides polysaccharides. All these methods lead to the formationinofcombination well-definedwith and interactions. The growing interest in biodegradable polymers, especially with CDs, is related with their biocompatibility and reversibility the application of macrocyclic molecules in combination with biodegradable polymers, especially with of host-guest interactions which leads to the stimuli-responsive supramolecular systems [11,12]. (b) β-CD, β-CD, (c) γ-CD, n-number of glucopiranose units
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