Abstract
In accordance with the World Cancer Report, cancer has become the leading cause of mortality worldwide, and various therapeutic strategies have been developed at the same time. In the present study, biocompatible magnetic nanoparticles were designed and synthesized as high-performance photothermal agents for near-infrared light mediated cancer therapy in vitro. Via a facile one-pot solvothermal method, well-defined PEGylated magnetic nanoparticles (PEG–Fe3O4) were prepared with cheap inhesion as a first step. Due to the successful coating of PEG molecules on the surface of PEG–Fe3O4, these nanoparticles exhibited excellent dispersibility and dissolvability in physiological condition. Cytotoxicity based on MTT assays indicated these nanoparticles revealed high biocompatibility and low toxicity towards both Hela cells and C6 cells. After near-infrared (NIR) laser irradiation, the viabilities of C6 cells were effectively suppressed when incubated with the NIR laser activated PEG–Fe3O4. In addition, detailed photothermal anti-cancer efficacy was evaluated via visual microscope images, demonstrating that our PEG–Fe3O4 were promising for photothermal therapy of cancer cells.
Highlights
IntroductionCancer has become the main cause of the death worldwide, which has overtaken heart-related disease
Over the past decade, cancer has become the main cause of the death worldwide, which has overtaken heart-related disease
Scanning electron microscope (SEM) image and transmission electron microscope (TEM) image shown in Figure 2A,B indicated the obtained product was roughly spherical with a mean diameter of 30 nm
Summary
Cancer has become the main cause of the death worldwide, which has overtaken heart-related disease. Noble metal-based nanostructures, Cu-based semiconductor nanoparticles, carbon-based nanomaterials, as well as organic polymers and assembly have been well prepared as powerful PTT agents to kill cancer cells both in vitro and in vivo [13–21]. Promising, these agents cannot achieve the essential clinical implementation due to their unknown long-term toxicity. Recent studies have demonstrated the design and construction of magnetic nanocomposites and their photothermal effect against bacteria and cancer cells [32–34] These systems only focused on the final results of PTT instead of detailed studies including systemic cytotoxicity of nanoagents and induced photothermal toxicity under different treatments. Visual microscope images based different staining methods further demonstrated the unexceptionable photothermal anti-cancer efficacy of our PEG–Fe3O4 upon NIR laser irradiation with a low laser power density and a short irradiation period
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