Biocompatible Magnetic Hydrogel Nanocomposite Based on Carboxymethylcellulose: Synthesis, Cell Culture Property and Drug Delivery

Abstract

In this report, the synthesis of a novel biocompatible magnetic hydrogel nanocomposite based on carboxymethyl cellulose (CMC), as an eco-friend, biocompatible and green polysaccharide, is described via a facile one pot approach using magnetic iron oxide nanoparticles (MIONs) as a crosslinker. The structure of the prepared MION–CMC hydrogel nanocomposite was examined by various analytical techniques such as FTIR spectroscopy, TGA thermal analysis, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). The MIONs were generated in situ during the hydrogel formation with an average diameter size of 10 nm and a narrow size distribution. The sample was superparamagnetic with large saturation magnetization at room temperature. MION–CMC hydrogel nanocomposite showed a good ability for releasing of doxorubicin as an anticancer drug at pH 7 with case II (relaxational) transport mechanism. This outcome demonstrated that MION–CMC hydrogel nanocompositeis an attractive biocompatible candidate for widespread biomedical applications, particularly in controlled drug-targeting delivery.