Abstract
Ginger has a long reported history as a spice, and India is the largest cultivator of ginger in the world. The study was aimed to develop sustained release herbal polymeric nano-formulation with [6]-Gingerol for anti-microbial activity without any adverse effect on the environment. [6]-Gingerol-loaded polymeric nanoparticles were developed by the single emulsification solvent evaporation method. 4%w/v Polyvinyl alcohol (PVA) was used as an aqueous phase, while [6]-Gingerol and Eudragit in acetone were used as an organic phase. The Box-Behnkendesign (BBD) was used to determine the effect of independent variables on responses. The particle size, zeta potential, and % entrapment efficiency were recorded as 319± 3.32 nm,+26±1.11 mV, and 78±0.89, respectively
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