Abstract
Photothermal therapy (PTT) using biocompatible nanomaterials have recently attracted much attention as a novel candidate technique for cancer therapy. In this work we report the performance of newly synthesized multidentate chitosan oligosaccharide modified gold nanorods (AuNRs-LA-COS) as novel agents for PTT of cancer cells due to their excellent biocompatibility, photothermal stability, and high absorption in the near-infrared (NIR) region. The AuNRs-LA-COS exhibit a strong NIR absorption peak at 838 nm with a mean length of 26 ± 3.1 nm and diameter of 6.8 ± 1.7 nm, respectively. The temperature of AuNRs-LA-COS rapidly reached 52.6 °C for 5 min of NIR laser irradiation at 2 W/cm2. The AuNRs-LA-COS had very low cytotoxicity and exhibited high efficiency for the ablation of breast cancer cells in vitro. The tumor-bearing mice were completely ablated without tumor recurrence after photothermal treatment with AuNRs-LA-COS (25 µg/mL) under laser irradiation. In summary, this study demonstrated that AuNRs-LA-COS with laser irradiation as novel agents pave an alternative way for breast cancer therapy and hold great promise for clinical trials in the near future.
Highlights
Photothermal therapy (PTT) has recently attracted considerable attention as a promising alternative for effective cancer therapy [1]
The lipoic acid (LA)-chitosan oligosaccharide (COS) was employed to replace cetyltrimethyl ammonium bromide (CTAB) on the surface of the AuNRs synthesized by the seed-mediated route
The preparation process of AuNRs-LA-COS for photothermal therapy is illustrated in Scheme 1a,b and Figure S1
Summary
Photothermal therapy (PTT) has recently attracted considerable attention as a promising alternative for effective cancer therapy [1]. Gold nanorods (AuNRs) have recently attracted considerable attention as promising nanomaterials for their photothermal responsive properties such as strong absorption in the NIR. AuNRs have limited clinical use due to cytotoxicity (toxicity to cells) caused by the residual CTAB To reduce such cytotoxicity, the marine biopolymer chitosan oligosaccharide (COS) is widely used for surface modification of. Chitosan is a natural biopolymer and an attractive biomaterial for therapeutic applications because of their excellent biocompatibility, biodegradability, and nontoxicity. The major drawback of chitosan is its poor solubility at neutral pH [25,26] To overcome these inherent drawbacks, COS was developed to serve as a novel candidate for biomedical applications. By combining characteristics of these materials AuNRs-LA-COS have gained increased attention for PTT due to their excellent biocompatibility, photothermal stability, and high absorption in the NIR region. We developed AuNRs-LA-COS as novel agents for photothermal therapy
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