Abstract
Biomaterials applications have rapidly expanded into different fields of sciences. One of the important fields of using biomaterials is dentistry, which can facilitate implantation, surgery, and treatment of oral diseases such as peri-implantitis, periodontitis, and other dental problems. Drug delivery systems based on biocompatible materials play a vital role in the release of drugs into aim tissues of the oral cavity with minimum side effects. Therefore, scientists have studied various delivery systems to improve the efficacy and acceptability of therapeutic approaches in dental problems and oral diseases. Also, biomaterials could be utilized as carriers in biocompatible drug delivery systems. For instance, natural polymeric substances, such as gelatin, chitosan, calcium phosphate, alginate, and xanthan gum are used to prepare different forms of delivery systems. In addition, some alloys are conducted in drug complexes for the better in transportation. Delivery systems based on biomaterials are provided with different strategies, although individual biomaterial has advantages and disadvantages which have a significant influence on transportation of complex such as solubility in physiological environments or distribution in tissues. Biomaterials have antibacterial and anti-inflammatory effects and prolonged time contact and even enhance antibiotic activities in oral infections. Moreover, these biomaterials are commonly prepared in some forms such as particulate complex, fibers, microspheres, gels, hydrogels, and injectable systems. In this review, we examined the application of biocompatible materials in drug delivery systems of oral and dental diseases or problems.
Highlights
Lotfollah Kamali Hakim,1,2,3 Mohsen Yazdanian,1 Mostafa Alam,4 Kamyar Abbasi,5 Hamid Tebyaniyan,6 Elahe Tahmasebi,1 Danial Khayatan,7 Alexander Seifalian,8 Reza Ranjbar,1,2 and Alireza Yazdanian 9
Drug delivery systems based on biocompatible materials play a vital role in the release of drugs into aim tissues of the oral cavity with minimum side effects. erefore, scientists have studied various delivery systems to improve the efficacy and acceptability of therapeutic approaches in dental problems and oral diseases
We examined the application of biocompatible materials in drug delivery systems of oral and dental diseases or problems
Summary
Lotfollah Kamali Hakim ,1,2,3 Mohsen Yazdanian ,1 Mostafa Alam ,4 Kamyar Abbasi ,5 Hamid Tebyaniyan ,6 Elahe Tahmasebi ,1 Danial Khayatan ,7 Alexander Seifalian ,8 Reza Ranjbar ,1,2 and Alireza Yazdanian 9. We examined the application of biocompatible materials in drug delivery systems of oral and dental diseases or problems. Us, multiple actions of microorganisms that have collective or synergistic effects on expanding or initiating the cavity that exerts antimicrobial treatment are not adequate for caries and multiple microbial disorders, which do not obey classical Koch’s postulates [3]. Oral infections such as periimplantitis, periodontitis, dental caries, and oral candidiasis occur due to microbial dysbiosis rather than specific species of bacteria. Is review study discussed biomaterials effects and their drug delivery application in different dental problems Devices and formulation attributed to biomaterials protect sensitive drugs and refine the retention time of active ingredients from days to months with due attention to the improvement of results of therapeutic approaches, individual compliance, and comfort. ere have been developed to improve drug delivery system strategies through different polymers and micro- or nanoparticles to prohibit the formation of biofilm [11] (Figure 1). is review study discussed biomaterials effects and their drug delivery application in different dental problems
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