Abstract
This research focuses on the synthesis of multi-walled carbon nanotubes (MWCNTs) decorated with TiO2 nanoparticles (NPs) and incorporated in cellulose acetate-collagen film in order to obtain a new biomaterial with potential biomedical applications and improved antimicrobial activity. The successful decoration of the MWCNTs with TiO2 NPs was confirmed by several structural and morphological analysis, such as Fourier transformed infrared spectroscopy, Raman spectroscopy, X-ray diffraction and transmission electron microscopy. The obtained nanocomposites were further incorporated into cellulose acetate-collagen films, at different concentrations and absorption kinetics, antimicrobial activity and in vitro biocompatibility of the obtained films was investigated. The antimicrobial tests sustained that the presence of the nanocomposites into the polymeric matrix is an important aspect in increasing and maintaining the antimicrobial activity of the polymeric wound dressings over time. The biocompatibility and cytotoxicity of the obtained films was evaluated using cellular viability/proliferation assay and fluorescent microscopy which revealed the ability of the obtained materials as potential wound dressing biomaterial.
Highlights
multi-walled carbon nanotubes (MWCNTs) used in this study were obtained by chemical synthesis, purified and functionalised in our previously study [31] and the decoration of the MWCNTs with nanoparticles was performed more
The obtained MWCNTs were used as template and stabiliser for nanoparticles formation in order to obtain the nanotubes decoration
The specific bands of MWCNTs are present, at 1597.63 cm–1 (G band), which refers to the crystalline nature of the MWCNTs and the band at 1346.29 cm–1 (D band), which indicates the distortions on the MWCNTs surface
Summary
In the past several years, medicine has faced real challenges regarding the bacterial spread, mostly because bacteria have evolved in order to survive antimicrobial medications by developing resistance mechanisms [1]. This issue continues to remain a major problem for hospitals and contribute significantly to the rate of morbidity, mortality and cost of care, that aggravates the problem mainly in developing countries where resources are scarce and staffs are always in short supply [2,3]. Often administrated in combination, results in selection of multidrug resistant nosocomial strains which belong mainly to several bacterial species, such as Gram-positive (i.e., Staphylococcus aureus, Streptococcus sp., Micrococcus sp.) and
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