Abstract
In this study, poly-lactic acid (PLA), nanohydroxyapatite (NHA), and graphene nanoplatelets (GNP) were blended to develop a nanocomposite material suitable for load-bearing bone implants with the potential for strain-sensing applications. The tensile properties and impact strength of the PLA-NHA nanocomposite were analyzed, as these are crucial biomechanical properties for load-bearing and strain-sensing applications. It was found that the impact strength decreased by 7.9% (0.05 wt% GNP) and 25.7% (0.1 wt% GNP) with increasing GNP loading compared to 0.01 wt% GNP. Besides, the biocompatibility of nanocomposites (PLA-NHA, PLA-mNHA, and PLA-mNHA-GNP) was evaluated through in-vitro analysis by attaching MG63 cells to the nanocomposites and observing their proliferation and differentiation over 7 and 21 days of incubation. The biocompatibility of the prepared nanocomposites was determined based on their ability to attach with MG63 cells, thus allowing the cells to proliferate and enhance their ability to differentiate. Results showed that the PLA-5wt%NHA nanocomposite provided better cell spreading compared to pure PLA, while the PLA-5wt%mNHA nanocomposite had the highest rate of cell proliferation. The biocompatibility of the nanocomposites was further confirmed by field emission scanning electron microscope (FESEM) imaging, MTT assays, and alkaline phosphatase (ALP) assays.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
