Abstract
ObjectiveThe objective of the present study was to verify the hypothesis that no difference in biocompatibility exists between different orthodontic adhesives.Material and MethodsThirty male Wistar rats were used in this study and divided into five groups (n=6): Group 1 (control, distilled water), Group 2 (Concise), Group 3 (Xeno III), Group 4 (Transbond XT), and Group 5 (Transbond plus Self-Etching Primer). Two cavities were performed in the subcutaneous dorsum of each animal to place a polyvinyl sponge soaked with 2 drops of the respective adhesive in each surgical loci. Two animals of each group were sacrificed after 7, 15, and 30 days, and their tissues were analyzed by using an optical microscope.ResultsAt day 7, Groups 3 (Transbond XT) and 4 (Xeno III) showed intense mono- and polymorphonuclear inflammatory infiltrate with no differences between them, whereas Groups 1 (control) and 2 (Concise) showed moderate mononuclear inflammatory infiltrate. At day 15, severe inflammation was observed in Group 3 (Transbond XT) compared to other groups. At day 30, the same group showed a more expressive mononuclear inflammatory infiltrate compared to other groups.ConclusionAmong the orthodontic adhesive analyzed, it may be concluded that Transbond XT exhibited the worst biocompatibility. However, one cannot interpret the specificity of the data generated in vivo animal models as a human response.
Highlights
Orthodontic adhesives are used to provide effective union between composite and dental structure
The most common substances SUHVHQW LQ DGKHVLYH V\VWHPV VKRZ D ZHOO GH¿QHG cytotoxic effect1,6,15. These adhesives are used in moist media and often on contaminated surfaces without compromising their adhesion, but different compounds can be released during the aqueous phase11, such as non-polymerized free monomers from resin materials5
In vivo studies17,19 show that non-polymerized resin compounds released from dental adhesives cause D SXOS LQÀDPPDWRU\ UHVSRQVH ZKLFK LV YLVLEOH DQG chronic8
Summary
Orthodontic adhesives are used to provide effective union between composite and dental structure. The most common substances SUHVHQW LQ DGKHVLYH V\VWHPV VKRZ D ZHOO GH¿QHG cytotoxic effect. The most common substances SUHVHQW LQ DGKHVLYH V\VWHPV VKRZ D ZHOO GH¿QHG cytotoxic effect1,6,15 These adhesives are used in moist media and often on contaminated surfaces without compromising their adhesion, but different compounds can be released during the aqueous phase, such as non-polymerized free monomers from resin materials. In vivo studies show that non-polymerized resin compounds released from dental adhesives cause D SXOS LQÀDPPDWRU\ UHVSRQVH ZKLFK LV YLVLEOH DQG chronic. Recent studies have shown presence of macrophages together with resin compounds following restorative procedure, in which a SHUVLVWHQW DQG FKURQLF LQÀDPPDWRU\ UHVSRQVH ZDV observed over a period of 300 days. Many research studies on the biocompatibility of dental materials are currently being performed. The aim of the present work was test the hypothesis that there is no difference in biocompatibility between the adhesives used for attaching orthodontic accessories
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