Abstract
This paper investigated the biocompatibility of nanoporous TiO2coating on NiTi shape-memory alloy (SMA) prepared via dealloying method. Our previous study shows that the dealloying treatment at low temperature leads to 130 nm Ni-free surface titania surface layer, which possesses good bioactivity because of the combination of hydroxyl (OH−) group in the process of dealloying treatment simultaneously. In this paper, the biological compatibility of NiTi alloy before and after dealloying treatment was evaluated and compared by direct contact method with dermal mesenchymal stem cells (DMSCs) by the isolated culture way. The interrelation between the biological compatibility and surface change of material after modification was systematically analyzed. As a consequence, the dealloying treatment method at low temperature could be of interest for biomedical application, as it can avoid sensitization and allergies and improve biocompatibility of NiTi shape-memory alloys. Thus it laid the foundation of the clinical trials for surface modification of NiTi memory alloy.
Highlights
Nowadays, nickel-titanium (NiTi) shape-memory alloy (SMA) becomes one of important biomedical metal materials because of its special shape-memory effect, the hyperelasticity, and excellent biocompatibility [1, 2]
XRD research shows that because of the thinner membrane formation after dealloying the diffraction peak of alloy substrate phase remained predominant, but having the titanium dioxide diffraction peak of faint sharp titanium ore phase and rutile phase appeared after processing, surface formed the titanium oxide
Nanoporous TiO2 coatings on NiTi alloy were prepared via dealloying method
Summary
Nickel-titanium (NiTi) shape-memory alloy (SMA) becomes one of important biomedical metal materials because of its special shape-memory effect, the hyperelasticity, and excellent biocompatibility [1, 2]. NiTi alloy containing high-concentration nickel (atomic ratio at 50%) can have a large number of nickel ions dissolved out after corrosion; especially in body fluid containing chlorine ion, point corrosion-resistant performance is not ideal, which will cause larger chronic host negative response, such as sensitization, teratogenicity, and even carcinogenic change [3]. These negative properties make NiTi alloy in the body of safety questioned, and patients are worried, which become one of the obstacles for NiTi alloy biomedical application. The nanoporous surface can obviously improve the cellular compatibility [13]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
