Abstract
Abstract Magnetic nanoparticles are highly promising for the usage in various biomedical applications including magnetic particle imaging (MPI), cancer hyperthermia treatment or as drug carriers. The present study aims at assessing in vitro biocompatibility of two commercially available magnetic iron oxide nanoparticle formulations: dextran-based magnetic nanoparticle synomag-D and bionized nanoferrite BNF-starch. Biological performance of both nanoparticle formulations were studied in human endothelial cells by analyzing cell viability and nanoparticle internalization in order to judge their suitability as theranostics.
Highlights
Magnetic iron oxide nanoparticlesMagnetic nanoparticles have attracted high consideration as potent theranostics such as for diagnostic magnetic resonance imaging, thermal cancer therapy, cell tracking and drug delivery [1,2]
Magnetic nanoparticles are highly promising for the usage in various biomedical applications including magnetic particle imaging (MPI), cancer hyperthermia treatment or as drug carriers
The present study is focussed on the evaluation of the suitability of two types of magnetic iron oxide nanoparticles for biomedical applications by analyzing their biocompatibility with human endothelial cells
Summary
Magnetic nanoparticles have attracted high consideration as potent theranostics such as for diagnostic magnetic resonance imaging, thermal cancer therapy, cell tracking and drug delivery [1,2]. They offer unique properties comprising superparamagnetism, surface-to-volume ratio, high surface area, and easy separation methodology, disclosing their great potential in the biomedical field. Synomag-D particles possess a maghemite (γ-Fe2O3) core of nanoflower-shaped nanocrystallites with a dextran shell and a hydrodynamic particle diameter of 50 nm. BNFstarch is composed of cubic magnetite (Fe3O4) crystals coated with hydroxyethyl starch while reaching a hydrodynamic particle diameter of 100 nm. The surface of the particles was functionalized with amino groups for covalent binding of the red fluorescent (redF) dye DY555–N-hydroxysuccinimide ester (Dyomics, Germany)
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