Biocompatibility of ionic liquid tagged terpyridine complexes with potent biological activity

Abstract

The current work deals with the study of novel and bioactive ionic liquid tagged terpyridine ligand and their complexes were synthesized using first row transition metal ions. The synthesized IL tagged complexes were characterized by UV, FT-IR, 1H NMR, 13C NMR, HRMS spectroscopic studies and also the structure of the complexes was confirmed by its spectral data. Moreover, the antibacterial, antifungal, antioxidant and anticancer studies were carried out to exhibit the bioactivity of the complexes. The antimicrobial studies of newly synthesized complexes were tested against five bacterial and two fungal strains by disc diffusion method. The iron complexes of terpyridine shows outstanding activity than the reference with zone of inhibition of 22-32 mm against the evaluated microorganisms. Furthermore, the antioxidant activity of the terpyridine complexes was assessed by phosphomolybdenum and NO radical scavenging assay. The reducing power of the synthesized complexes has shown potent antioxidant activity than the standard. Especially, Cu-tpy-IL and Zn-ttpy-IL have shown good radical scavenging activity exhibits an IC50 value of 42.45 and 40.85 µg/mL respectively. In addition, the anticancer activity of the complexes was analyzed by SRB assay. The report suggested that the complexes of Cu-ttpy-IL and Zn-ttpy-IL exhibiting prominent role in anticancer activity against HeLa and HT-29 cell lines possessing a GI50 value of <10 µg/mL. The obtained results revealed that the bioactive synthesized complexes could be used as a derivative in the field of drug inventions.