Abstract
Magnetic targeted drugs delivery system (MTDDS) is a new targeted drug system, which can greatly reduce the dosage and improve the therapeutic efficiency of medicine. Currently superparamagnetic ferric oxide plays important function as targeted drug in the treatment of tumors, but cytotoxicity was still regarded as side effect in the process of drug. In this paper, we take advantage of drug carrier (ferric oxide) toxicity controlling cancer cell growth in cancer treatment, increasing targeted drug efficiency. We applied the modified chemical precipitation method to prepare polylactic acid (PLA) coated high-purity superparamagnetic Fe3O4 nanoparticles for targeted drug, characterized PLA/Fe3O4 microspheres physical and chemical properties, and then investigated cytotoxicity influence of PLA/Fe3O4 nanomagnetic microspheres as carrier for normal liver cells (7701) and liver cancer cells (HePG2) in different concentration; results of MTT and hemolysis and micronucleus test showed that carrier restrained the growth of HePG2 in special concentration, meanwhile the proliferation rate of liver cells was not affected. The study demonstrates that compared with liver cell, liver cancer cells (HepG2) are easy to be disturbed by PLA/Fe3O4 nanomagnetic microsphere, which have higher sensitivity and absorption ability. We hope to take advantage of the susceptible property of cancer cells for carriers to improve targeted drug function.
Highlights
Magnetic nanoparticles play important function as targeted drug in the treatment of tumors, which control the site of drug delivering
In order to further enhance targeted drug capacity of nanomagnetic particles [4, 5], scientists carry out study from three aspects: (1) selecting appropriate polymer as membrane coating particles, which help to increase dispersion and biocompatibility of microsphere; (2) modifying the surface, as nanoparticles may bond with kinds of functional group (-OH, -COOH, -NH2, -CHO, etc.) on the surface of material, which are beneficial for connecting important bioactive substance by adsorption or covalent bonding way; (3) improving particles superparamagnetic properties by adjusting diameter of microsphere, thickness of polymer membrane, and so on, which lead to targeted drug separation and tropism under magnetic field
Magnetic targeted drug delivery system consists of magnetic polymer microspheres and drug, and drug combines with microspheres by physical adsorption, entrapment, and chemical bonding methods
Summary
Magnetic nanoparticles play important function as targeted drug in the treatment of tumors, which control the site of drug delivering. Ni and Ramanujan [7] used similar way that initiated lactide (LA) reaction In these experiments, researchers usually pay more attention to toxicity effect of drug delivering, releasing process on the cell or tissue in lesion, and biocompatibility of drug carriers. Few people take notice that carrier materials have certain potential of toxicity effect for cancer cell growth in targeted drug. At first we prepared Fe3O4 magnetic nanoparticle coated by PLA and characterized structure, morphology, and biocompatibility of PLA/Fe3O4 microsphere; lastly it was investigated whether or not PLA/Fe3O4 nanomagnetic microspheres as carrier cause cytotoxicity for growth of normal liver cells and liver cancer cells. This paper focused on toxicity effect of drug carrier to cancer cell proliferation for increasing targeted drug efficiency
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