Abstract
The present study reports on the in vivo biocompatibility investigation and evaluation of the effects of liposomes containing dexketoprofen in somatic sensitivity in rats. Method: The liposomes were prepared by entrapping dexketoprofen in vesicular systems stabilized with chitosan. The in vivo biocompatibility was evaluated after oral administration in white Wistar rats: Group I (DW): distilled water 0.3 mL/100 g body weight; Group II (DEX): dexketoprofen 10 mg/kg body weight (kbw); Group III (nano-DEX): liposomes containing dexketoprofen 10 mg/kbw. Blood samples were collected from caudal lateral vein one day and seven days after the substance administration, to assess the eventual hematological, biochemical, and immunological changes. The investigation of somatic pain reactivity was performed using the hot plate test, to count the latency time response evoked by the thermal paws’ noxious stimulation. Results: Original liposomes entrapping dexketoprofen, with mean size of 680 nm and good stability, were designed. Laboratory analysis indicated no substantial variances between the three treated groups. The treatment with liposomes containing dexketoprofen resulted in a prolongation of the latency time response, statistically significant in the interval between 90 min and 10 h, in the hot plate test. Conclusions: The use of liposomes with dexketoprofen proved a good in vivo biocompatibility in rats and prolonged analgesic effects in the hot plate test.
Highlights
Nanomedicine offers highly valuable research and practical application tools in the medical field, for improving the current methods of prevention, diagnosis, and targeted therapy in various pathological conditions, from simple inflammatory to neoplastic diseases [1]
Contemporary papers highlight many medical applications of nanotechnology in the pharmaceutical field, given the design of new nanoparticulate systems for the transport and release of active substances, as well as in the field of regenerative medicine, in preventive medicine, diagnosis, and treatment of diseases [3]
Chitosan was dissolved in 0.5% (v/v) acetic acid solution with 99.5% purity purchased from the Chemical Company
Summary
Nanomedicine offers highly valuable research and practical application tools in the medical field, for improving the current methods of prevention, diagnosis, and targeted therapy in various pathological conditions, from simple inflammatory to neoplastic diseases [1]. Contemporary papers highlight many medical applications of nanotechnology in the pharmaceutical field, given the design of new nanoparticulate systems for the transport and release of active substances, as well as in the field of regenerative medicine (nano-robots and devices used in cell regeneration), in preventive medicine, diagnosis, and treatment of diseases [3]. The water-soluble salt of this non-steroidal anti-inflammatory drug, the (+)-(S)-2-(3-benzoylphenyl) propionic acid tromethamine derivative (dexketoprofen tromethamine), possesses analgesic, antipyretic, and anti-inflammatory properties, and is used in the treatment of acute and chronic pain in medical, as well as in post-surgery, conditions [13,14,15]
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