Biocompatibility and Effectiveness of a Novel, Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial

André Correia,Jaime Del Río Highsmith,Carlos F Almeida,Pedro Molinero-Mourelle,Luís Azevedo,Maria Correia

doi:10.3390/ijerph18073398

Abstract

To assess the clinical efficacy of a novel, organic olive oil-based denture adhesive and its effect on Candida albicans growth in maxillary edentulous individuals wearing complete dentures, individuals were selected from two dental schools in Portugal and Spain. Twenty-eight complete dentures were relined, following a standardized protocol. The novel product (test) was compared with a commercialized adhesive (control) and Vaseline (placebo) randomly assigned in a cross-study design. The retention resistance was measured with a gnathometer and a dynamometer. The patients related outcome evaluations with a five-point questionnaire, and the Candida albicans growth in a Sabouraud dextrose agar (SDA) medium was used to evaluate differences between the placebo and experimental product. Twenty-three participants were included. The dynamometer evaluation showed significant differences between not using a denture adhesive and using either (experimental, p = 0.03; control, p = 0.04) and no significant differences between the two adhesives (p > 0.05). In the subjective analysis, the experimental adhesive showed a significantly longer effectiveness (p = 0.001), and the control reported better results in taste (p = 0.03) and in chewing (p = 0.001). The test adhesive showed better (p < 0.001) Candida albicans growth inhibition. The experimental adhesive showed longer effectiveness than the control and the placebo with a better inhibition capacity for the growth of Candida albicans. Patients reported better abilities for speech, chewing, taste, and retirement in the control adhesive.

Highlights

Complete dentures continue to be a reliable treatment option for edentulous patients because of medical and economic constraints [1]
The null hypothesis was rejected since significant differences were found between the assessed adhesives
The present study selected dentures with a maximum wearing period of two years according to Maeda et al [26]; a denture needs to be relined after approximately 27 months

Summary

Introduction

Complete dentures continue to be a reliable treatment option for edentulous patients because of medical and economic constraints [1]. Dentures’ retention, stability, and support depend on the intimate adaptation of their base to the soft and hard tissues, the peripheral seal fir, and saliva’s presence between the dentures and the intraoral tissues [2,3]. In several clinical situations, saliva’s natural adhesiveness and the denture base design and extension cannot provide enough stability and retention. In those cases, denture adhesives proved to be a good option for patients by increasing comfort levels and improving function performance [4,5]. Effective action mechanisms of denture adhesives depend on the combination of physical and chemical forces [6]. When in contact with saliva, denture adhesives increase by 50 to

Methods

Results

Discussion

Conclusion