Abstract
Microbial multidrug resistance presents a real problem to human health. Therefore, water-soluble polymers based on poly(aspartate-co-succinimide) were synthesized via reaction of poly(aspartate-co-succinimide) with bis-quaternary ammonium or quaternary salts. The resultant copolymers were characterized by various techniques such as FTIR, TGA, 1HNMR, 13CNMR and elemental microanalysis. Antimicrobial activities of the new onium salts were investigated against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Salmonella typhi, and the fungi; Candida albicans, Aspergillus niger, Cryptococcus neoformans and Aspergillus flavus by agar diffusion method. Antimicrobial activity was studied in terms of inhibition zone diameters, in addition to the estimation of minimal inhibitory concentration (MIC) of the prepared compounds. A. niger and E. coli were the most affected microorganisms among the tested microorganisms with an inhibition zone of 19–21 (mm) in case of biocides, (V) and (VII). The obtained results showed that the quaternary onium salts have higher activity compared to the aspartate copolymer with MIC concentrations of 25 mg/mL for (VII) and (V) and 50 mg/mL for (VI) and (IV).
Highlights
In recent years, the management of infectious disease has become a challenge, and microbial infections are a top concern [1]
We developed new antimicrobial water-soluble polymers based poly(aspartate-co-succinimide) through reaction with different quaternary ammonium and phosphonium salts
Water-soluble copolymer-based on poly(aspartate-co-succinimide) containing quaternary salts were prepared by using different sources like TMEDA, tetraethylammonium bromide (TEAB) and methyltriphenylphosphonium bromide (MTPPB)
Summary
The management of infectious disease has become a challenge, and microbial infections are a top concern [1]. The nanoparticles are small, and can be inhaled by breathing from the environment These materials can first affect the respiratory tract via deposition in the human lungs and move to other organs of the body like the liver, brain, etc. There is a wide range of different polymeric materials available naturally and can be prepared synthetically Some of these have significant low antimicrobial action against the drug-resistant microorganisms. Due to their reduced residual toxicity, increased lifetime and enhanced antimicrobial properties, such polymers can be used in different fields like food packaging and medicine [14,15]. The antimicrobial action of the new onium salts was investigated against different types of pathogenic microbes (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, Salmonella typhi, and the fungi; Aspergillus niger, Candida albicans, Cryptococcus neoformans and Aspergillus flavus) by estimation of inhibition zone diameters as well as the minimum inhibitory concentration (MIC)
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