Abstract
Angiotensin I (AI), a nonactive decapeptide generated by action of the enzyme, renin, on a glycoprotein substrate, angiotensinogen, is converted to the active pressor octapeptide angiotensin II (AII) by an exopeptidase first identified and isolated in plasma by Skeggs et al.1 who accordingly named this angiotensin-converting enzyme (ACE). This enzyme was later found to be the same enzyme as Kininase II, and is able to hydrolyze bradykinin and various other peptides.2,3 Most of the conversion of circulating AI to AII occurs during passage through the lungs.4 However, this dipeptidyl carboxypeptidase has been found to be widely distributed throughout the body as a membrane bound ectoenzyme on the surface of vascular endothelial cells and epithelial cells of many organs.5–7
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