Abstract
Both central and peripheral dopamine (DA) receptors were divided into two subtypes. Central DA receptors were named D1 and D2;2 peripheral DA receptors were defined DA1 and DA2. This chapter reviews the main data available concerning the biochemical characteristics of peripheral DA receptors and describes where these receptor sites are localized in the cardiovascular system, kidney, and adrenal gland. The characterization of DA receptors in the heart has been accomplished primarily using tritium-labeled agonists instead of antagonists. A comparison between papers so far published on the radioreceptor characterization of peripheral dopaminergic receptors and those attempting to analyze where these receptor sites are located shows that the subject of the anatomical localization of DA receptors was rather neglected. The chapter provides direct evidence that a detailed analysis of peripheral DA receptor localization may contribute to the understanding of basic physiological mechanisms or may help to hypothesize the mode of action of dopaminergic drugs.
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