Biochemical study on some adipocyto-kines in chronic renal failure: Their relationship to endothelial dysfunction and inflammation

Abstract

Chronic renal failure has been associated with impaired immunityand subclinical inflammation involving cytokines derived from adiposetissue – adipocytokines. Deteriorating renal function may increase overallinflammatory responses because of the decreased renal clearance of factors that are directly or indirectly involved in inflammation. Declining renal function may also affect the levels of additional inflammatory molecules such as C-reactive protein (CRP) and interleukin-6.The aim of the study was to assess visfatin and apelin in correlation with markers of endothelial cell injury and inflammation in 20 patients with CRF and 20 age- and sexmatched healthy controls.We assessed visfatin and apelin, markers of: coagulation: TAT (thrombin-antithrombin complexes); fibrinolysis: tPA (tissue plasminogen activator) and PAI-1 (plasminogen activator inhibitor- 1); endothelial function/injury: ICAM (intracellular adhesion molecule), VCAM (vascular cell adhesion molecule), CD40L and E-selectin and inflammation: hsCRP andIL-1â. Visfatin, apelin, TAT, ICAM, VCAM, CD40L, PAI-1, E-selectin, hsCRP, IL-1â and triglycerides were elevated while serum albumin and t-PA were decreased in CRF patients when compared with the control group.Significant positive correlations werefound between Visfatin on one hand and each of apelin, t-PA, PAI-1, Eselectin, ICAM, VCAM, hsCRP, IL-1â, CD40L and triglycerides on theother hand in patients with CRF.Also, Significant positive correlations werefound between Apelin and each of IL-1â, E-selectin, ICAM, VCAM,creatinine and triglycerides in CRF.KEY WORDS: CRF, adipocytokines, endothelial dysfunction andinflammation.