Abstract
The current study aimed at assessment of peripheral blood lymphocyte cells in hepatitis C patients compared to Healthy controls and evaluating the potential diagnostic role and relation to disease severity and complications. Patients and Methods: The present study included 27 hepatitis C patients and 27 healthy controls. Full history and clinical assessment of hepatitis C were performed for patients. Blood samples were collected from patients and controls for estimation of laboratory parameters (AST, ALT, T. Bilirubin, D. Bilirubin, PCR, CBC (WBCs, PLT, and HB), and T-cell activation marker (CD69). The flow- cytometer was used to measure CD69 %. Results: The results of this study revealed significant increase in AST, ALT. D. Bilirubin, and CD69%. In hepatitis C patients comparing with controls. In addition, hepatitis C patients had statistically significant decrease in Albumin and PLT count less than controls. No statistically significant decrease was detected in HB and WBCs count in hepatitis C patients comparing with healthy control. and no statistically significant increase in T. Bilirubin in hepatitis C group more than control was detected. Conclusion: The present study could suggest that CD69 cells are important determinants of immune status and prognosis in hepatitis C patients.
Highlights
HCV is hepatotropic, and in many countries chronic hepatitis C is a leading cause of liver disease including fibrosis, cirrhosis and hepatocellular carcinoma
Primed specific CD4+ cells are essential to allow the adequate activation of specific cytotoxic T cells by secretion of T helper (Th)-1 cytokines (Larrubia et al, 2009) subsequently, these specific cytotoxic T lymphocytes (CTL) play a major role in resolution of spontaneous infection because they are able to recognize the infected cells and destroy them by cytolytic mechanisms
Our results showed that The Cluster of differentiation (CD69) % had a high significant increase in the HCV infected group when compared to control group (P value=0.004) as shown in Table (1) and Figs. (1and 2)
Summary
HCV is hepatotropic, and in many countries chronic hepatitis C is a leading cause of liver disease including fibrosis, cirrhosis and hepatocellular carcinoma. Serum HCV RNA cannot be detected before a window of 1-3 wk. Symptoms are mild and non-specific, so patients often do not seek medical assistance. Elevated ALT levels indicating the first signs of liver injury can be detected 4-12 wk. After infection, and wide fluctuations are common. Severe liver inflammation is uncommon, and fulminant hepatitis is rare. Seroconversion may occur between 4 and 10 wk. After exposure (Santantonio T et al, 2008). HCV persists in 50–85% of infected patients, and once chronic infection is established, spontaneous clearance is rare
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