Biochemical Study of Antioxidants in Diabetic Patients

Abstract

The research included a biochemical study of lipid peroxidation and other antioxidants and their relation with Diabetes Mellitus ( D.M.) type I (50 patients) and type II (100 patients). Measurement of some biochemical parameters were performed. The results of statistical analysis showed a significant increase of malondialdehyde peroxy nitrite radical and superoxide dismutase activity in serum of patients with type II when compared with normal. A significant decrease was also observed in concentration of vitamin C, vitamin E, glutathione, selenium, ceruloplasmine, uric acid and zinc in serum of diabetic patients of both types and peroxy nitrite radical in type I only. Other factors such as age, duration of the disease states, glucose concentration on lipid peroxidation and other antioxidants concentration were also performed. The results predicated that there was a significant increase in malondialdehyde with age in both types of diabetes and a significant decrease in serum concentration of vitamin C and E, glutathione with age in type II. A significant increase in MDA concentration with a decrease in vitamin C were also found in patients with increasing the duration of disease and a significant increase in malondialdehyde concentration with increasing blood glucose concentration, while there was a significant decrease in vitamin C and E concentrations.