Biochemical study of angiotensin II, electrolytes and vitamin D in obese patients

Abstract

Background: Obesity is one of the most prevalent health issues impacting kids and teens in both industrialized and developing countries, yet it is a complex illness brought on by both inherited and environmental factors, Obesity develops as a result of a combination of low energy expenditure (such as exercise) and excessive calorie intake. Obesity-related problems such hypertension, metabolic disease, cardiovascular disease, and kidney disease are linked by Ang II and electrolytes. This study was designed to evaluate the alteration of Angiotensin II, electrolytes, Vit D in obese individuals. Methods: 88 persons with ages range between (20-55) years. Angiotensin II was determined by ELISA method. While serum Electrolytes estimated by GE300 Electrolyte analyzer, and Vitamin D determined by High pressure liquid chromatography (HPLC). Results: The findings of the present research reveals a significant increase in Ang II concentration (p<0.001) and decrease in Vit D (p<0.003), iCa (p<0.000) level in obese patients when compared with a control group. The results of linear regression analysis show positive correlations (r = 0.37, p < 0.01) of Ang II concentration with Sodium in obese group, and the same analysis show negative correlations (r =-0.49, p < 0.001) of BMI with Vit D in obese group.