Abstract
Lycopene is a fat-soluble hydrocarbon carotenoid pigment that gives tomatoes their red color with a high capacity for scavenging free radicals. Thioacetamide (TAA) is one of several agents that produce structural and functional changes, not only in liver, but also in other tissues as kidneys, thymus, spleen, intestine and lungs. The present study was carried out on male albino rats to investigate the effects of intraperitoneally (i.p.) injection of thioacetamide, as a single dose of 150 mg/kg b.wt. in adult male albino rats and the possible prophylactic action of tomato juice. Thioacetamide toxicity were evidenced by an increase in thiobarbituric acid reactive substance (TBARS) which is an indicator for lipid peroxidation concomitant with decline in the iducenes of antioxidant capacity inducing, reduced glutathione (GSH), glutathione reductase activity (GSH-Rx) superoxide dismutase (SOD), glucose-6-phosphate dehydrogenase (G6PD) and catalase (CAT) the kidney. Treatment with tomato juice (7.9 ml/kg b.wt.) daily for 2 weeks before TAA injection, significantly reduced kidneys TBARS concentration, at the same time, ameliorated the TAA-induced inhibition of GSH content as well as , GSH-Rx, SOD,G6PD and CAT activities. Thioacetamide caused an inhibition in the Na + /K + adenosine triphosphatase activity of the kidneys , elevation of sodium ions and water content paralleled with a decrease in potassium content. At the same time an increase in serum K and urine Na levels concomitant with a decrease in serum Na and urine K levels were observed. The results revealed an increase in the kidney, serum and urine activities of alkaline phosphatase accompanied with an elevation in urea and creatinine in serum and urine. Administration of tomatojuice before TAA ameliorated most of these parameters. It is concluded that, ingestion of tomatoes, may provide natural protection against nephrotoxicity damage caused by thioacetamide.
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