Abstract
The behavior of sodium hyaluronate injected into the anterior chamber of rabbits was investigated using a 1% (w/v) solution of sodium hyaluronate having a molecular weight of 800K. Although the aqueous humor contained a considerable amount of reduced ascorbic acid, the molecular weight of sodium hyaluronate injected into the anterior chamber did not change. This was due to existence of a protecting factor for degradation of sodium hyaluronate in a low molecular weight fraction of the aqueous humor. The injected sodium hyaluronate was found to aggregate with proteins in the aqueous humor within 2 hrs. However, this aggregation did not affect the degradation of sodium hyaluronate with ascorbic acid. The hyaluronic acid content in the iris-ciliary body increased about three times as much as the normal level 2 hrs after the sodium hyaluronate injection. This result suggests that the injected sodium hyaluronate is not only eliminated through the angular aqueous plexus but also through the iris-ciliary body, followed by digestion with hyaluronidase in those tissues.
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