Abstract
Some factors affecting on the metabolism of cyclobarbital (EHB) by the rat liverpreparation were examined.Sex difference was especially shown in the formation of 3-OH-EHB, but no difference in that of 3-keto-EHB was shown.The pretreatment of female rats with EHB enhanced both the formation of 3-OHEHB and that of 3-keto-EHB in approximately same proportion as controls. However, the pretreatment with 3-OH-EHB increased the formation of 3-OH-EHB and decreased that of 3-keto-EHB from EHB. The conversion of 3-OH-EHB to 3-keto-EHB was depressed by the pretreatment with testosterone or 3-OH-EHB. On the other hand, the conversion of 3-keto-EHB to 3-OH-EHB was stimulated by such a treatment. Another metabolite of EHB, 3-keto-EHB, has not stimulatory effect on the EHB-metabolism.The removal of the adrenal glands did not prevent the stimulatory effect of EHB.
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