Abstract
Serum lipoproteins in rats with fatty liver, which was induced by feeding an amino acid imbalanced diet containing 8% casein supplemented with 0.3% of DL-methionine, were analyzed. Three classes of serum lipoproteins, VLDL, LDL and HDL, were isolated by flotation in the ultracentrifuge and their concentration and chemical composition were determined. In serum VLDL of the imbalanced group, the concentration of TG was significantly higher than those for the control group, and that of apoprotein was maintained at the normal level. These results suggest that this type of fatty liver is not due to a block in the transport of hepatic TG to the plasma. On the contrary, the administration of DL-ethionine resulted in a reduced level of TG of VLDL.
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