Abstract
A series of salicylic acid derivatives was studied for duration of blood salicyl levels in the rabbit. The series comprised salicylic acid, sodium salicylate, acetylsalicylic acid, a solubilized acetylsalicylic acid, nicotinyl salicylate, salicyoyl-beta-alanide, acetylsaligenin, the salicylic acid ester of succinic acid, acetylsalicylaldehyde diacetate, the amide of o-aminobenzoic and salicylic acids, and saligenin. The effective compounds were studied in combination and singly. Of this series, the most effective single compound was found to be nicotinyl salicylate and the most effective combination was one of nicotinyl salicylate and saligenin.
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