Abstract
The effect of the intraperitoneal injection of UDMH on rat tissue sulfhydryl levels, serum GOT, and urinary amino acid excretion has been studied. The approximate LD 50 in rats was found to be 100 mg/kg. Rats given a single injection of 80 mg/kg of UDMH show no changes in liver or brain sulfhydryl levels, nor are serum GOT levels altered by this dose. Analyses of urine samples show that rats injected with UDMH at levels of 40, 60, or 80 mg/kg excrete correspondingly increased amounts of amino acids in the urine during the subsequent 24-hour period. It appears that this is a general increase in amino acid excretion, and abnormalities associated with specific amino acids are not apparent. Histopathologic studies do not reveal any tissue pathology as a result of this single injection of UDMH. Since neurologic symptoms are present in these animals, the present findings tend to support the evidence for a biochemical mechanism mediating the acute toxic effects of UDMH.
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