Abstract
Biochemical Profile, Liver and Kidney Selenium (Se) Status during Acanthamoebiasis in a Mouse Model
Highlights
The aim of the present study was to determine biochemical parameters and Se concentrations in the main detoxication organs in immunocompetent and immunosuppressed mice infected by Acanthamoeba sp. at the early stage of infection
Immunological status affected Se levels in the liver and kidney of mice infected by Acanthamoeba sp
Selenium supplementation decreases the parasitemia of Trypanosoma sp. infections and reduces important parameters associated with diseases such as anemia and parasite-induced organ damage (DA SILVA et al 2014)
Summary
The aim of the present study was to determine biochemical parameters and Se concentrations in the main detoxication organs in immunocompetent and immunosuppressed mice infected by Acanthamoeba sp. at the early stage of infection. Immunological status affected Se levels in the liver and kidney of mice infected by Acanthamoeba sp. This parasite influenced the activity of serum AST regardless of the host’s immunological status. Se is a cofactor for glutathione peroxidase (GPx), selenoprotein P, and thioredoxin reductase, playing a significant role in maintaining redox homeostasis and sufficient activity of immunocompetent cells, and in the release of inflammatory mediators (TINGGI 2008) This element has a diverse effect on the immune system, being immunosuppressive at high doses, and immunostimulatory at low doses. Parasitic diseases are sometimes accompanied by elevated and/or reduced Se concentrations in the liver and kidney, and may alter the regulation of trace mineral metabolism and homeostasis (PILARCZYK et al 2008).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
