Abstract

Tissue from two functioning human thyroid adenomas was studied in vitro after testing with TSH in vivo. The adenoma of the first patient appeared to concentrate TcO4− in vivo and responded to TSH with an increase in 131I uptake though the patient was not hyperthyroid. The second patient was hyperthyroid and exogenous TSH injection caused a significant increase in serum T3. In vitro, the tissue from the first adenoma did not trap iodide although the quantity of iodine organified was at least 6-fold greater than that found with either samples of the surrounding normal tissue or in 5 other studies of normal human thyroid. However, despite supranormal amounts of newly synthesized MIT and DIT, the quantity of T4 formed was quite small. Further evidence of decreased T3 and T4 synthesis in the adenoma was found in the decreased T3 and T4 content of the pronase hydrolysate of the adenoma as measured by immunoassay. T4 and T3 levels in the adenoma wore 3.8 and 0.66 μg/g wet wt, respectively, contrasted with levels...

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