Abstract
The effect of fluoride on acid production by Streptococcus sanguis ATCC 10556 was compared under anaerobic and aerobic conditions. The rate of acid production under constant-pH and pH-free-fall conditions was determined during glucose metabolism by resting cells. Anaerobic glycolysis was inhibited more strongly by fluoride than was aerobic glycolysis. Intracellular levels of 3-phosphoglyceric, 2-phosphoglyceric, and phosphoenolpyruvic acids were lower under anaerobic conditions than under aerobic conditions. Thus, S. sanguis had a low phosphoenolpyruvate (PEP) potential under anaerobic conditions. This low PEP potential was suggested to account for the more effective fluoride inhibition of enolase and, consequently, the reduced transport of sugar by the PEP-dependent phosphotransferase system of this micro-organism.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
