Biochemical Mechanisms of Action of Natural Ingredients from the Vaginal Applicators for the Management of Preinvasive Cervical Lesions

Violeta Coravu,Corina Aurelia Zugravu,Mara Mergeanu,Monica Mihaela Cirstoiu,Maria Sajin,Natalia Turcan

doi:10.37358/rc.21.4.8466

Abstract

A successfully implemented screening program for cervical cancer is essential for detecting cervical intraepithelial lesions which offer the possibility of appropriate management and monitoring, implicitly the limitation of the progression to an invasive form of cancer. For different grades of squamous intraepithelial lesions, the use of vaginal tablets or applicators based on various natural substances as hyaluronic acid, beta-glucan and Coriolus Versicolor is possible with the purpose of expectative management or prior and post excisional intervention. We present the incidence trend of abnormal Pap smear results for the last five years in the University Emergency Hospital of Bucharest, with a summary of the literature regarding the biochemical mechanism of the main natural components from vaginal tablets used in the management of precancerous cervical lesions HPV induced and we share our personal experience with three clinical cases that benefited from this therapy. As there is a therapeutic window between the Pap-smear result, colposcopy and preparing for intervention, local treatment with natural components is a suitable choice as it is easy to use, inexpensive and efficient. The conclusion we reached is that the vaginal treatment with natural substances can be useful in terms of improving the local inflammatory process on the one hand and lubricating and regenerating tissues with the improvement of subsequent procedural performance on the other.

Highlights

In the context in which we have an efficient prevention opportunity for cervical cancer, this pathology remains of a high incidence worldwide
For different grades of squamous intraepithelial lesions, the use of vaginal tablets or applicators based on various natural substances as hyaluronic acid, beta-glucan and Coriolus Versicolor is possible with the purpose of expectative management or prior and post excisional intervention
Precancerous cervical lesions are conditions that can evolve into cancer, and these lesionsare treatable with a correct management protocol applied

Summary

Introduction

In the context in which we have an efficient prevention opportunity for cervical cancer, this pathology remains of a high incidence worldwide. According to the U.S Preventive Services Task Force 2018 - is recommended the beginning of screening for cervical cancer at 21 years by performing Pap smear alone at every three years and co-testing every five yearsfor women aged 30-65 years alternatively to Pap smear every three years and HPV testing alone (3). The principle beyond these recommendations is that through co-testing the highest number of CIN 3 (cervical intraepithelial neoplasia) can be detected and it associates the highest percentage of false-positive rate (4)

Objectives

Methods

Results

Conclusion