Abstract
In contrast to metabolic bone diseases characterized by dramatic changes in bone turnover such as Paget’s disease of bone or renal osteodystrophy, osteoporosis is a condition in which subtle modifications of the bone remodeling activity can lead to a substantial loss of bone mass after a long period of time. This explains why most conventional markers are normal in a patient with osteoporosis and why there have been efforts to develop more sensitive biochemical markers of bone turnover. The rate of formation or degradation of the bone matrix can be assessed either by measuring a. prominent enzymatic activity of the bone-forming or resorbing cells-such as alkaline and acid phosphatase activity-or by measuring bone matrix components released into the circulation during formation or resorption
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