Abstract
Mitochondria obtained from nonfatty livers of male rats fed alcohol for 4 months showed reduced contents of cytochromes a- a 3 and b and decreased activity of cytochrome oxidase and mitochondrial H 2O 2 production. Neither succinate dehydrogenase and NADH dehydrogenase activities, nor the cytochromes c and c 1 and ubiquinone content were affected. Alcohol ingestion also impaired the in vitro incorporation of [ 14C]leucine into the protein of the hepatic mitochondrial membranes. The data suggested that chronic interference of ethanol with the synthesis of protein may be expected to result in lowered values of components of the electron transport chain and thus in interference with mitochondrial properties.
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