Abstract
2 Abstract: This study determined the influence of doses of halofantrine hydrochloride, a phenanthren e methanol drug used in the therapeutic treatment of malaria on the estradiol levels of female wistar rats. A suspension of the drug at a dose of 0.5ml/kg and 1ml/kg body weight three times at six hourly intervals were administered orally to different groups of mature female rats for 5 and 10 days duration, control groups received similar treatment doses of normal saline. The animals were sacrificed on the 5th and 10th day after drug administration by cervical dislocation. Whole blood samples were collected for white blood cell count. From the plasma, the hormonal level was determined by radio-immunoassay and the activities of AST, ALT and ALP were also determined. The level of estradiol following 5 and 10 days treatment was higher significantly (p<0.05) in both groups compared to the control. The activities of ALT, AST and ALP increased significantly (p<0.05). The white blood cell count also increased in a dose dependent manner. These findings suggest that the drug might have some hepatotoxic effects.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
