Abstract
This study was designed to compare the effect of two types of viral hepatitis A and E (HAVand HEV) on liver functions in Iraqi individuals by the measurement of biochemical changesassociated with hepatitis.The study performed on 58 HEV and 66 HAV infected patients compared with 28 healthysubjects. The measured biochemical tests include total serum bilirubin, serum transminases (ALTand AST) alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT).The study showed that adolescent and young adults (17-29) years, were mostly affected byHEV while children (5-12) years were frequently affected by HAV. The severity of liver damage inHEV patients was higher than HAV patients as a result of high serum transaminase levels.Patients with HEV were associated with cholestasis due to high serum level of ALP and GGTcompared to HAV patients.
Highlights
Hepatitis E virusHepatitis E virus (HEV) is an acute, icteric self—limiting disease, which is spread widely in many tropical and subtropical countries, where it occurs both in the form of epidemic of variable magnitude or sporadically [1]
Acute liver failure secondary to hepatitis E infection is common in pregnancy and associated with mortality rate up to 20% [6] because both in women and her fetus are at risk, escalated production of progesterone during pregnancy leads to downregulation of cellular immune function
The virus mediates injury by both cellular and non cellular immune mechanisms an IgM antibody appears early in the course of illness and persist 2-6 months and IgG antibody, appears towards the end of acute illness presist for several years and conveys lifelong immunity, Hepatitis A occurs in sporadics and epidemic forms with incubation period of 15-50 days Epidemic have been associated with water borne and food borne countries, outbreak have occurred through infected food handlers in restaurants
Summary
Hepatitis E virus (HEV) is an acute, icteric self—limiting disease, which is spread widely in many tropical and subtropical countries, where it occurs both in the form of epidemic of variable magnitude or sporadically [1]. The virus mediates injury by both cellular and non cellular immune mechanisms an IgM antibody (anti HAV IgM) appears early in the course of illness and persist 2-6 months and IgG antibody, appears towards the end of acute illness presist for several years and conveys lifelong immunity, Hepatitis A occurs in sporadics and epidemic forms with incubation period of 15-50 days Epidemic have been associated with water borne and food borne countries, outbreak have occurred through infected food handlers in restaurants. Hepatitis A can be prevented by immunization with an inactivated vaccine which highly effective [11]
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Schedule a callMore From: Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)
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