Abstract
The α-adrenergic antagonists yohimbine, prazozin and phentolamine, but not the α-adrenergic agonists, block voltage-dependent Na + channels of rat brain synaptosomes. The lipid-soluble neurotoxins (veratridine, aconitine, grayanotoxins and ceveratrum alkaloids), which cause a permanent activation of the Na + channels by acting at the same receptor site as yohimbine, compete with [ 3H]yohimbine for its binding to rat brain α 2-adrenoreceptors. The calcium channel inhibitors verapamil and D 600 also block the Na + channel and recognize α 2-adrenoreceptors.
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