Abstract
Thyroid hormone effects on the developing rat brain were analyzed regarding the nucleic acid contents and the rate of protein synthesis using PTU induced neonatal hypothyroid rat as a model for human congenital hypothyroidism. Significantly reduced amount of total DNA contents per brain and protein/DNA ratio were demonstrated in both cerebrum and cerebellum of the hypothyroid rat after 14 days, suggesting the disturbed cell formation and cell growth in the hypothyroid rat brain. And the maturation of the cerebellum extended later into postnatal life than does that of the cerebrum. Additional evidence by the reduced rate of protein synthesis in the hypothyroids would correlate with these altered morphogenesis. Postmitochondrial supernatant (PMS) obtained from both control and hypothyroid brain homogenate, which was used for the experiment of protein synthesis, contained the same amount of the RNA contents. Therefore the defective protein synthesis might be attributed to the disturbed translational process of the genetic message in protein.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
