Abstract
Doxorubicin (DOX ) is an anthracycline derivative antibiotic, used as anticancer agent, it causesgeneration of free radicals and induces oxidative stress, associated with cellular injury and participatein hepatonephrotoxicity in normal human cells .The protective effect of Spirulina Platensis (SP) , afilamentous blue green algae , on Doxorubicin induced oxidative stress and hepatotoxicity was evaluatedin male rats. Oral administration of water extract of Spirulina (1000 mg/kg/b.wt) for six weeks followingan acute toxic dose of Doxorubicin ( 1.0 mg/kg/b.wt) , reduces the hepatotoxicity and attenuatesdoxorubicin-induced stress .The post-treatment with Spirulina reduces the activity of Liver markerenzymes such as serum alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Renalfunction disorders represented by urea. The ratio of decrease were lower in the first three weeks ifcompared with the last three weeks. On the other hand, Oral administration of Spirulina extract for sixweeks following an acute toxic dose of Doxorubicin, led to an obvious increase in the activity ofantioxidant Parameters including Catalase ( CAT ) and Super Oxide Dismutase ( SOD ). The resultsclearly demonstrate that Spirulina treatment augments the antioxidants defense mechanism in Doxinduced toxicity and provides evidence that it may have a therapeutic role in free radical mediateddiseases.
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