Abstract
The mechanism of the action of ethionine (ethyl analog of methionine) on sea urchin embryo development was investigated. 1. 1. The ethionine treatment inhibited protein, RNA and DNA synthesis. 2. 2. The inhibition of protein and RNA synthesis occurred before the appearance of degeneration of the primary mesenchyme cells. 3. 3. The inhibition of DNA synthesis was concurrent with the appearance of morphological alterations. 4. 4. The DNA methylation in vivo did not appear to be inhibited by ethionine. 5. 5. Ethionine was incorporated into embryo proteins. 6. 6. Radioactivity from ethyl-labeled l-ethionine was detected in DNA, mainly in its pyrimidine bases, but no evidence of DNA ethylated bases was found.
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