Biochemical Effects Of B-Success (A Nigerian Herbal Remedy) On Liver And Heart Of Albino Rats

Abstract

Introduction: Although Nigerian herbal practitioners have shown some improvements in the standardization of doses and dosages, many herbal supplements have poor toxicological assessment to ensure human safety. A toxicological assessment of B-Success herbal supplement commonly used in Nigeria was carried out on liver, heart and kidney of adult albino rats. Method: Twenty albino rats divided into four groups of five rats each were used. Twenty male rats were divided into four dose groups of five rats each namely 0.00, 315,630, 945mg/kg/day (representing 0, 25, 50 and 75% of the LD50 of B-Success herbal supplement) orally for 90 days. Animals had access to deionized water and were fed ad libitum with rat chow for 90 days. The feed and fluid consumption of the animals were measured on daily basis while the body weight was measured weekly. Animals were anaesthetized after 90 days, bled and bilirubin, creatinine, high density lipoprotein cholesterol (HDL),low density lipoprotein (LDL), alanin transaminase (ALT), and aspartate transaminase (AST) were measured.Result: The alanin transaminase (ALT), aspartate transaminase (AST) and urea of 630, 945 mg/kg/day dose groups were significantly increased compared to control. While only the creatinine value of 945mg/kg/day dose group was significantly increased compared to control p 0.05) the bilirubin levels compared to control. The total cholesterol, high density lipoprotein (HDL) cholesterol of all the B-Success treated groups were significantly increased p<0.05 compared to control. The low density lipoprotein (LDL) cholesterol values of 630, 945mg/kg/day groups were significantly decreased p<0.05 compared to control.Conclusion: Taken together B-Success may be toxic to liver and kidney and protective to heart in albino rats at the doses studied.