Abstract
Improvement of antimicrobial metabolites by Saccharothrix flava VSM-3 using full factorial design and chemotype analysisUshakiranmayi Managamuri, Muvva Vijayalakshmi, Venkata Siva Rama Rama Krishna Ganduri, Satish Babu Rajulapati, Sudhakar Poda
Highlights
The use of superoxide dismutase (SOD) has become a rational therapeutic approach in efforts to minimize oxygen radicalinduced damage due to its role in the metabolism of superoxide anionic radicals and its potent antioxidant known in nature
A fusion of SOD Citrus limon (SOD_Cl) to a gliadin peptide, QQPYPQPQPF (GliSOD_P61) but not SOD_Cl was found to penetrate Caco2 cells indicating the peptide enhanced SOD permeability (Utami et al, 2017). Another fusion SOD protein, GliSOD_P51 was constructed with a gliadin peptide, LGQQQPFPPQQPYPQPQPF to be tested for its permeability
The gliadin peptide sequence was fused to the amino terminus of a complete amino acid sequence of SOD_Cl
Summary
The use of superoxide dismutase (SOD) has become a rational therapeutic approach in efforts to minimize oxygen radicalinduced damage due to its role in the metabolism of superoxide anionic radicals and its potent antioxidant known in nature. Several administration routes of SOD have been studied (Carillon et al, 2013). Oral administration of SODs is limited by their degradation in the gastrointestinal tract due to acidic pH in the stomach and the presence of digestive enzymes. A fusion of SOD_Cl to a gliadin peptide, QQPYPQPQPF (GliSOD_P61) but not SOD_Cl was found to penetrate Caco cells indicating the peptide enhanced SOD permeability (Utami et al, 2017). Another fusion SOD protein, GliSOD_P51 was constructed with a gliadin peptide, LGQQQPFPPQQPYPQPQPF to be tested for its permeability
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