Abstract
The content of C-reactive protein (CRP), interleukin-1 (IL-1), endothelin -1(E-1), soluble adhesion molecules of vascular endothelium-1 (sVCAM-1) and soluble molecules of intercellular adhesion -1 (sICAM-1 ) in peripheral blood of patients suffering from neurologic syndromes of dorsolumbar osteochondrosis (lumbalgia, lumboishialgia, lumbosacral radiculupathy) in recrudescence phase was investigated. CRP concentration in blood serum was determined by highly sensitive quantitative method (hs-CRP), based on the reaction of immunoprecipitation with reagent sets “Thermoscientific” firm, USA. Endothelin-1, sVCAM-1, sICAM-1 content in blood serum was determined by means of immunoenzymometric analysis method. The research was carried out with standard diagnostic reagent set of the “BioMedica”, “Bender MedSystem»” (BMS201, BMS 232) firm, (Austria), and the apparatus “Multiscan” of the Labsystem firm (Finland). Statistically significant (p < 0,05) concentration increase of C-reactive protein, interleukin-1 (IL-1), endothelin -1, sVCAM-1 and sICAM-1 in peripheral blood serum in patients having lumbosacral radiculopathy in comparison with the test-group and with groups of patients suffering from syndromes of lumbalgia and lumboishialgia was found out.
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