Abstract
The objective of this study was to determine the effects of the general anesthesia on same biochemical changes in donkeys. The anesthesia was induced by intravenous (IV) injection of romifidine 0.1 mg/kg as a premedication, after 5 minutes induction of general anesthesia by (IV) of mixture midazolam 0.1 mg/kg and ketamine hydrochloride 2.2 mg/kg in the same syringe. The maintenance of anesthesia was performed by (IV) infusion of a mixture of the midazolam 0.065 mg/kg/hr. and ketamine 6.6 mg/kg/hr. The biochemical parameters changes in serum levels of Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline phosphate (ALP) activity as liver enzymes and serum glucose were estimated in zero, 15, 30, 60, 120, 240 and 480 minutes. The results revealed significant differences (P<0.05) in the means of AST (U/L) between zero 199.6 with 30 min 192.5 and 60 min 191.5. No significant differences (P>0.05) in mean enzyme activity of the ALT and ALP. Serum glucose results were shown no significant differences (P>0.05) in the (control, 15, 30 minutes) and (60,120 and 240) respectively and significant differences in between and within 480 minutes. The general anesthesia in this protocol was good and had little effect on the liver function and showed increase in serum blood glucose in donkeys.
Highlights
The α-2-adrenoceptor agonists drugs have been recognized as worldwide use in veterinary medicine for their sedative, analgesic and muscle relaxation properties in large and small animals [1]
Alkaline phosphate (ALP) values of this study showed no significant difference in the M ± stander error (SE) values of the ALP between donkeys at level of P
Serum glucose mg/dl was slowly increased in the 10 minutes (97.2±0.513 -100.77±0.855), and increased to (101.4±0.805) at the 15 minutes the serum blood glucose still increase to the end of experiment
Summary
The α-2-adrenoceptor agonists drugs have been recognized as worldwide use in veterinary medicine for their sedative, analgesic and muscle relaxation properties in large and small animals [1]. Romifidine has been available since 1985 [3] It has been used successfully for sedation, analgesia, and premedication in horses in several countries since 1988 [4] with effects similar to other α-2 adrenoreceptor agonists [5]. Midazolam is a short-acting benzodiazepine with hypnotic, anticonvulsant, muscle-relaxant and anxiolytic properties. In clinical practice, it was using for the induction of anesthesia [6]. The plasma and urinary glucose act as broad indicators of the severity of any disturbance to carbohydrate metabolism, the homeostatic mechanisms for maintaining blood glucose are influenced by intestinal absorption and both hepatic and tissue metabolism. Plasma or serum should be rapidly separated after collection to avoid the effects of erythrocyte glycolysis
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