Abstract
Abstract Rats were exposed to the products of pyrolysis of polytetrafluoroethylene (PTFE) containing hydrolyzable fluoride equivalent to 50 ppm COF2 for one hour daily. After one exposure, urinary excretion of fluoride was four times normal. Weight loss of exposed animals indicated inhibition of metabolism. Changes in succinic dehydrogenase activity in vivo correlated with exposure to pyrolysis products of PTFE and with urinary fluoride concentrations. Toxic effects of daily sublethal exposures were found to be cumulative. The metabolic inhibition observed was reversible. The toxic syndrome of daily inhalation of pyrolysis products of PTFE is compatible with descriptions of fluoride poisoning.
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