Abstract
The aim of our study was evaluation of prevalence of uncomplicated and complicated urinary tract infections (UTIs) among patients with UTIs associated with Gram - negative bacteria and analysis of prognostic risk factors in complicated UTIs. Weretrospectivelyanalyzed the medical records of inpatients with diagnosis of UTI based on clinical, biological and microbiological assay. Susceptibility tests for different antimicrobial categories were performed. Risk factors in complicated UTIs were correlated with pathogens� susceptibility. A total of 96 eligible patients were analyzed. Complicated UTIs were identified in 66.67% cases. The most frequent uropathogens isolated were E.coli and Klebsiella species. Exrtrarenal factors and nephropathic disease were the most common factors associatedwith an increased prevalence of multi -drug resistant isolates. Knowledge of the spectrum of the possible pathogens and local resistance patterns are very important for the antibacterial treatment outcome.
Highlights
The aim of our study was evaluation of prevalence of uncomplicated and complicated urinary tract infections (UTIs) among patients with UTIs associated with Gram - negative bacteria and analysis of prognostic risk factors in complicated UTIs
According to last European Centre for Disease Prevention and Control (ECDC) report, Romania records a significantly higher antimicrobial resistance compared to European average, mainly for Klebsiella pneumoniae and Enterococcus, while E. coli is dealing with an increase resistance in Europe [7]
Romania recorded a decrease of antimicrobial resistance of E. coli, but maintained an increased resistance for Klebsiella pneumoniae compared to European average[7].Risk factors associated with this etiology were renal and extrarenal
Summary
The aim of our study was evaluation of prevalence of uncomplicated and complicated urinary tract infections (UTIs) among patients with UTIs associated with Gram - negative bacteria and analysis of prognostic risk factors in complicated UTIs. According to last European Centre for Disease Prevention and Control (ECDC) report, Romania records a significantly higher antimicrobial resistance compared to European average, mainly for Klebsiella pneumoniae and Enterococcus, while E. coli is dealing with an increase resistance in Europe [7]. The most frequent pathogen identified in both uncomplicated and complicated UTIs were Escherichia coli(75.8% isolates) andKlebsiellaspp.(8.06% isolates).
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