Biochemical bone resorption markers during the healing of osteoporotic fractures

Abstract

This study investigated the progression and clinical relevance of biochemical resorption marker values during fracture healing in osteoporosis. In 44 patients with distal radius fractures and 29 patients without fractures, the blood and urine concentrations of pyridinoline (PYD), deoxypyridinoline (DPD), N-telopeptides (NTx), and bone sialoprotein (BSP) were recorded on the day of trauma as well as during further progression. All postmenopausal patients underwent bone density measurement. Accordingly, patients were divided into premenopausal, postmenopausal osteoporotic, and postmenopausal nonosteoporotic groups. Between the groups, PYD, DPD, and NTx showed significant differences in their initial values. However, their further relative progression was primarily affected by the chosen therapy. Bone resorption markers can diagnostically point to osteoporosis and are significant parameters in fracture healing.