Abstract

Etude des differences liees au sexe dans le metabolisme hepatique des medicaments (diazepam, digoxine, imipramine, phenobarbital…), avec interet particulier porte aux steroides. Article synthese rappelant quelques etudes effectuees chez l'homme, quelques modeles animaux utilises dans la litterature. Evaluation des processus susceptibles d'etre impliques: recherche des systemes enzymatiques responsables de cette difference de metabolisme, influence d'hormones regulant la difference de sexe

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