Abstract
<b>Galzigna, L., Ferraro, M. V., Manani, G., and Viola, A. (1973).</b><i>British Journal of Industrial Medicine,</i><b>30,</b> 129-133. <b>Biochemical basis for the toxic effects of triethyl lead.</b> The effects of triethyl lead (PbEt<sub>3</sub>) have been studied <i>in vitro</i> on the cholinesterase activity of rat diaphragm and <i>in vivo</i> on serum cholinesterase in the dog. PbEt<sub>3</sub> dramatically increases the duration of succinylcholine-induced myoneural block and pyridine-2-aldoxime methiodide (PAM) is able to counteract both cholinesterase inhibition and the effects on neuromuscular transmission. On the other hand, PbEt<sub>3</sub> catalyses the rearrangement of catecholamines to aminochromes <i>in vitro</i> and inhibits catecholamine effect on smooth muscle contraction. The toxicity of PbEt<sub>3</sub> and particularly its action on the central nervous system can be explained by a combination of effects which might result from an upset of cholinergic and adrenergic central pathways due to the formation of endogenous psychotogenic complexes.
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